MatriDerm® Dermal Matrix

MatriDerm® Dermal Matrix is a unique collagen-elastin-template, which serves as a dermal replacement scaffold and can be applied both in a One-Step and Two-Step Procedure.

MatriDerm® Dermal Matrix

  • Open Porous Matrix

  • No Chemical Cross-linking

  • Native Collagen Fibers

  • Contains Elastin

Meet the Expert Webinar

MatriDerm® Clinical Performance

Restores Function1

The combination of Matriderm® Dermal Matrix with a split-thickness skin graft preserves sensory function and decreases donor site morbidity after radial forearm free flap (superior results to FTSG in skin sensibility, superficial radial nerve recovery and cosmetic outcome).

Modified according to Watfa W. et al., J Sex Med 2017, 14(10):1277-1284

* p< 0.0001

** Disabilities of the Arm, Shoulder, and Hand; A score of 100 represents the worst outcome and 0 represents no dysfunction

1. Compared to FTSG alone

Ensures Active Healing1

In diabetic foot ulcers the combination of MatriDerm with STSG lead to a shorter healing period compared to STSG alone.


Modified according to Jeon H. et al., ArchPlast Surg2013, 40(4):403-8

* p=0.010

1. Compared to STSG alone

Cost Effective

In an RCT the total surgical treatment costs of Full-thickness wounds treated with STSG alone or with MatriDerm Dermal Matrix and STSG were analyzed. The costs do not differ significantly.

Modified according to Hop M. et al., Burns 2013, 40(3):388-96

Improves Quality of Wound Healing1

Long term follow-up study of an intra-individual comparison of patients treated with STSG alone and with MatriDerm Dermal Matrix and STSG to analyze different skin parameter after 12 years of treatment. It demonstrate a long lasting effect on scar quality even after 12 years by the use of MatriDerm Dermal Matrix compared to STSG alone.


Modified according to Bloemen MC et al., Plast Reconstr Surg, 2010, 125(5):1450-9

1. Compared to STSG alone

* p< 0.05

MatriDerm® Scientific Rationale

MatriDerm® is able to preservecloseness to human dermis, acceleratecell invasion, elongation and proliferation and limitmyofibroblast formation and contraction. This scientific performance is as a result of our Advanced CryoSafe® Method which gently preserves the native structure with no chemical crosslinking.1

1. Böhm S et al.; Materials 2017; 10(9), 1086

PRESERVES

MatriDerm® Dermal Matrix preservescloseness to human dermis.

MatriDerm has similar ultrastructural features as native collagen fibre bundles in human dermis. The other processed dermal matrices show large fields with amorphous structures.

Dill, V. and Mörgelin, M. Int Wound J 2020; 17(3):618-630.

ACCELERATES

In an animal AV-Loop model number of new formed blood vessels were analyzed in wounds treated with either with MatriDerm® Dermal Matrix or competitor product. MatriDerm Dermal Matrix accelerates revascularization.

Schmidt VJ et al., Ann Plast Surg. 2017; 79(1):92-100

LIMITS

In vitro analysis of the formation of myofribroblast phenotype by α-SMA staining. MatriDerm® Dermal Matrix limits myofibroblast formation compared to competitor products1. Myofibroblast formation is associated with wound contraction2. By limiting myofibroblast formation wound contraction is limited.3, 4, 5

1. Dill V and Moergelin M, Int Wound J 2020; 17(3):618-630.

2. Kattan WM et al., J Coll Physicians Surg Pak 2017; 27:38-43.

3. De Vries H et al., Wound Repair Regen. 1994; 2(1):37-47.

4. De Vries HJ et al., Br J Dermatol. 1995; 132(5):690-7.

5. Hur GY, Seo DK, Lee JW., Burns. 2014; 40(8):1497-503.

*By measurement of α-SMA positive fibroblasts

MatriDerm® Surgical Procedure Flexibility

MatriDerm® Dermal Matrix Indications

  • MatriDerm® Dermal Matrix Indications

    MatriDerm® is used in combination with autologous split-thickness skin grafts (STSG) for the reconstruction of deep dermal defects and full-thickness skin wounds in plastic reconstructive surgery and in the surgical treatment of burns, trauma and dermatological diseases. It is also used in the treatment of graft requiring poorly healing wounds (e.g. chronic wounds).

    The aim of treatment is to construct a neo-dermis, in order to improve the quality of reconstituted skin, reduce scarring, prevent wound contraction and restore functionality. MatriDerm® can also be used under intact skin for the temporary separation of tissues, thereby preventing adherence, especially of tendons and their surrounding connective tissue, after injuries or surgical procedures.

  • Burns

  • Trauma & Acute Wounds

  • Chronic Wounds

  • Cancer Excision

  • Adhesion Barrier

  • Donor Sites

  • Mucosal Defects

WarningThis case study is intended for Health Care Professionals and contains graphic imagery

Please click through to continue to the next slide.

This patient (who is an Orthopedic Surgeon) underwent emergency debridement for necrotizing fasciitis of the lower leg.

Courtesy of I Younis, MBBCh, MRCS (Eng), MSc, FRCS (Plast), London, UK.

In order to save his leg and life almost all the skin, soft tissue and fascia of his lower leg were debrided including the vascular (paratenon layer) of the medial and lateral gastrocnemius tendons.

Courtesy of I Younis, MBBCh, MRCS (Eng), MSc, FRCS (Plast), London, UK.

NPWT with instillation and dwell time (NPWTi-d) was applied following debridement for further cleansing of the wound and to form a layer of granulation tissue over the musculature producing a smoother and more even wound bed surface prior to the application of the dermal template.

Courtesy of I Younis, MBBCh, MRCS (Eng), MSc, FRCS (Plast), London, UK.

NPWT with instillation and dwell time (NPWTi-d) was applied following debridement for further cleansing of the wound and to form a layer of granulation tissue over the musculature producing a smoother and more even wound bed surface prior to the application of the dermal template.

Courtesy of I Younis, MBBCh, MRCS (Eng), MSc, FRCS (Plast), London, UK.

Following this a Two-Step Procedure was used by bolstering two A4 size 2mm MatriDerm® Dermal Matrix templates with NPWT and a non-adherent silicone interface layer with the aim of obliterating the soft tissue cavity which was greater than 5mm. The MatriDerm® Dermal Matrix template was also used to bridge the exposed gastrocnemius tendons.

Courtesy of I Younis, MBBCh, MRCS (Eng), MSc, FRCS (Plast), London, UK.

The first NPWT dressing change showed good integration of MatriDerm® Dermal Matrix.

Courtesy of I Younis, MBBCh, MRCS (Eng), MSc, FRCS (Plast), London, UK.

After several changes of NPWT filling of the soft tissue defect was achieved with reduced area of exposed tendons lacking paratenon.

Courtesy of I Younis, MBBCh, MRCS (Eng), MSc, FRCS (Plast), London, UK.

To bridge the remaining area of tendons which lacked vascularity a smaller size 1 mm MatriDerm® Dermal Matrix was applied as a One-Step Procedure with a Split-Thickness Skin Graft at the same time that was bolstered with NPWT.

Courtesy of I Younis, MBBCh, MRCS (Eng), MSc, FRCS (Plast), London, UK.

Two years postoperatively, the reconstruction of this lower leg with Two-Step Procedure 2 mm and One-Step Procedure 1 mm MatriDerm® Dermal Matrix shows no soft tissue indentation with intact and stable skin over the tendons with full return to function.

The patient has returned to work as a full time Orthopedic Surgeon.

Courtesy of I Younis, MBBCh, MRCS (Eng), MSc, FRCS (Plast), London, UK.

MatriDerm Dermal Matrix Trauma Application Video - Necrotizing Faciitis - Two-Step Procedure

WarningThis case study is intended for Health Care Professionals and contains graphic imagery

Please click through to continue to the next slide.

Pre-operative: Hyperextension of the MCP joint – function is considerably limited.

Courtesy of L Kamolz, MD, Graz, Austria.

Pre-operative: Fist closure is not possible.

Courtesy of L Kamolz, MD, Graz, Austria.

Intra-operative: Complete excision of the scar tissue.

Courtesy of L Kamolz, MD, Graz, Austria.

Intra-operative: The scar tissue – laid back onto the wound bed for the photo – reveals the dimension of the scar contraction, the skin deficit and the substantial functional limitation.

Courtesy of L Kamolz, MD, Graz, Austria.

Long-term follow-up: Normal function of the hand without any limitations.

Courtesy of L Kamolz, MD, Graz, Austria.

Long-term follow-up: Normal function of the hand without any limitations.

Courtesy of L Kamolz, MD, Graz, Austria.

Long-term follow-up: Normal function of the hand without any limitations.

Courtesy of L Kamolz, MD, Graz, Austria.

Long-term follow-up: Normal function of the hand without any limitations.

Courtesy of L Kamolz, MD, Graz, Austria.

WarningThis case study is intended for Health Care Professionals and contains graphic imagery

Please click through to continue to the next slide.

Surgical approach at the musculus flexor digitorum brevis, preparation and release of the adhesive tissue.

Courtesy of U Graf, MD, Zurich, Switzerland.

Gentle pull through of a small sheet of dry 1 mm MatriDerm.

Courtesy of U Graf, MD, Zurich, Switzerland.

Wrapping of the tendon.

Courtesy of U Graf, MD, Zurich, Switzerland.

Final view before wound closure.

Courtesy of U Graf, MD, Zurich, Switzerland.

No reoccurrence of the claw toe and the patient no longer has an incorrect position and is able to wear his own shoes.

Courtesy of U Graf, MD, Zurich, Switzerland.

WarningThis case study is intended for Health Care Professionals and contains graphic imagery

Please click through to continue to the next slide.

A 60-year-old male with diabetic foot syndrome and a history of obesity and coronary heart disease, presented with a gangrenous right foot.

Courtesy of D Luedi, MD, Langenthal, Switzerland.

An emergency bedside debridement was performed and IV antibiotics were started. At the following surgical debridement, the 5th metatarsal bone was resected. The wound was further debrided with the use of maggots. The wound bed was prepared with gauze-based Negative Pressure Wound Therapy (NPWT), which was set at 120 mmHg.

Courtesy of D Luedi, MD, Langenthal, Switzerland.

At the time of wound closure, the excess granulation tissue was removed and a dry sheet of 1 mm MatriDerm® was applied on the wound bed, MatriDerm® was then moistened with Ringer’s lactate.

Courtesy of D Luedi, MD, Langenthal, Switzerland.

A split-thickness skin graft immediately followed in a One-Step Procedure.

Courtesy of D Luedi, MD, Langenthal, Switzerland.

A non-adherent wound contact layer was placed over the skin graft and the graft was fixated with NPWT. After 7 days, NPWT was ceased and the skin graft demonstrated good take rate and healing. The wound was dressed with fatty gauze dressings.

Courtesy of D Luedi, MD, Langenthal, Switzerland.

Two months post-operatively, wound healing had progressed well.

Courtesy of D Luedi, MD, Langenthal, Switzerland.

Three months post op, the wound showed stable wound closure and the patient was able to walk with a diabetic shoe.

Courtesy of D Luedi, MD, Langenthal, Switzerland.

Six months post op, the wound showed stable wound closure and the patient was able to walk with a diabetic shoe.

Courtesy of D Luedi, MD, Langenthal, Switzerland.

MatriDerm Dermal Matrix Application Video – Defect Lower Leg after an Infection – One-Step Procedure

MatriDerm Dermal Matrix Application Video – Amputated Forefoot – One-Step Procedure

MatriDerm® Further Details

Note:MatriDerm® Dermal Matrix is not available in the United States of America

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